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What is Gabapentin ?

Generic Gabapentin target is the treatment of seizures. Generic Gabapentin can also be used to relieve the pain of diabetic neuropathy and postherpetic neuralgia.  It is taken to prevent and treat hot flashes in women with menopause or breast cancer.

Gabapentin is an anticonvulsant or antiepileptic drug that is used alongside other medications to control and prevent seizures. It is also used to help relieve nerve pain a patient experiences following shingles (a painful rash due to herpes zoster infection) in adults. Is the generic version as good as the brand version?

Gabapentin is the generic version of Neurontin, and requires a prescription. All generic medications sold through Blink Health are FDA-approved. All FDA-approved generics must have the same strength, dosage form, safety and effectiveness as their brand-name counterparts.

Generic Gabapentin can be used together with other seizures medicines. Generic Gabapentin is acting by affecting certain nerves and chemicals which cause seizures and pain. It is anticonvulsant.

Generic name of Generic Gabapentin is Gabapentin.

Brand names of Generic Gabapentin are Gabapentin, Gabarone.

gabapentin-ingredients
gabapentin-ingredients

The precise mechanism through which gabapentin exerts its therapeutic effects is unclear.

The primary mode of action appears to be at the auxillary α2δ-1 subunit of voltage-gated calcium channels (though a low affinity for the α2δ-2 subunit has also been reported). The major function of these subunits is to facilitate the movement of pore-forming α1 subunits of calcium channels from the endoplasmic reticulum to the cell membrane of pre-synaptic neurons.

There is evidence that chronic pain states can cause an increase in the expression of α2δ subunits and that these changes correlate with hyperalgesia. Gabapentin appears to inhibit the action of α2δ-1 subunits, thus decreasing the density of pre-synaptic voltage-gated calcium channels and subsequent release of excitatory neurotransmitters. It is likely that this inhibition is also responsible for the anti-epileptic action of gabapentin.

There is some evidence that gabapentin also acts on adenosine receptors and voltage-gated potassium channels, though the clinical relevance of its action at these sites is unclear.

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How to use gabapentin ?

It’s important to read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist, before you begin taking gabapentin and each time you get a refill. If you have any questions, ask your clinician or pharmacist.

Take gabapentin by mouth, either with or without food as directed by your licensed medical professional. Your dosage is based on your medical condition, as well as your response to treatment. In children, the dosage is also based on their weight.

If you are taking the tablet form of gabapentin and your licensed medical professional directs you to split the tablet in half, take the other half-tablet at your next scheduled dose. Be sure to discard remaining half-tablets if you haven’t used them within 28 days of splitting them. If you are taking the capsules, always swallow them whole with plenty of water.

It is very important to follow your licensed medical professional’s dosing instructions exactly. During the first few days taking gabapentin, your licensed medical professional may gradually increase your dose so that your body can adjust to the medication.

To minimize the occurrence of side effects, take the very first dose at bedtime. To get the most benefit, take this medication regularly. Gabapentin will work best when the amount of medication in your body is kept at a constant level.

Therefore, take gabapentin at evenly spaced intervals at the same time(s) every day as prescribed. If taking this medication three times per day to control seizures, do not let more than 12 hours pass between doses, or you may increase the risk of having a seizure. Do not increase your dose or take this medication more frequently without consulting your licensed medical professional. Your risk of serious side effects can increase, and your condition will not improve any faster.

Do not stop taking this medication without consulting your licensed medical professional. Some conditions can become worse when gabapentin is stopped suddenly. If you wish to stop taking gabapentin, your dose may need to be gradually decreased.

Antacids containing aluminum or magnesium may interfere with the absorption of this medication. Therefore, if you are also taking an antacid, it is best to take gabapentin at least 2 hours after taking the antacid. Different forms of gabapentin (such as immediate-release, sustained-release, enacarbil sustained-release) are absorbed in the body differently.

Do not switch from one form to the other without consulting your licensed medical professional. Tell your licensed medical professional if your condition does not improve or if it worsens.

What you must know Before you buy Gabapentin Online

It’s also important to be aware of precautions and warnings around taking this medication.

Before taking gabapentin, tell your doctor or pharmacist if you are allergic to it; or to gabapentin enacarbil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, mental/mood problems (such as depression, thoughts of suicide), use/abuse of drugs/alcohol, breathing problems.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially swelling of the hands/ankles/feet, slow/shallow breathing, dizziness, or loss of coordination. Dizziness and loss of coordination can increase the risk of falling.

Children may be more sensitive to the side effects of this drug, especially mental/mood/behavior changes (such as hostility, problems concentrating, restlessness).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Gabapentin passes into breast milk. Consult your doctor before breast-feeding.

Gabapentin Dosage

Gabapentin Dosage Information
Gabapentin Dosage Information

Generic Gabapentin is available in:

300mg Low Dosage400mg Standard Dosage

Generic Gabapentin is available in tablets, liquid form and capsules(300 mg, 400 mg).

The dosage of Generic Gabapentin depends on the type of your disease and health state.

Take Generic Gabapentin tablets, liquid form and capsules orally at the same time every day with water.

Generic Gabapentin can be used together with other seizures medicines.

Take Generic Gabapentin 3 times a day with or without food.

If you want to achieve most effective results do not stop taking Generic Gabapentin suddenly.

Gabapentin Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Gabapentin Overdose

If you overdose Generic Gabapentin and you don’t feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Gabapentin overdosage: feeling drowsy, double vision, slurred speech, diarrhea, difficulties with breathing, problems with coordination.

Symptoms of gabapentin overdose may include: severe drowsiness, slurred speech, weakness. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Gabapentin Side effects

Generic Gabapentin has its side effects.

gabapentin-side-effects
gabapentin-side-effects

Get emergency medical help if you have signs of an allergic reaction to gabapentin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using gabapentin.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • increased seizures;
  • fever, rash, and/or swollen lymph nodes;
  • severe weakness or tiredness;
  • problems with balance or muscle movement;
  • upper stomach pain;
  • chest pain, new or worsening cough with fever, trouble breathing;
  • severe tingling or numbness;
  • rapid eye movement; or
  • kidney problems – little or no urination, painful or difficult urination, swelling in your feet or ankles.

Some side effects are more likely in children taking gabapentin. Contact your doctor if the child taking this medicine has any of the following side effects:

  • changes in behavior;
  • memory problems;
  • trouble concentrating; or
  • acting restless, hostile, or aggressive.

Common gabapentin side effects may include:

  • headache, dizziness, drowsiness, tiredness;
  • swelling in your hands or feet;
  • problems with your eyes;
  • coordination problems; or
  • (in children) fever, nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gabapentin Contra-indications

Do not take Generic Gabapentin if you are allergic to Generic Gabapentin components.

Do not take Generic Gabapentin if you are pregnant, planning to become pregnant. Avoid breast-feeding.

Be careful with Generic Gabapentin if you are taking morphine (such as MSIR, Avinza, Kadian), hydrocodone (in Vicodin, in Hydrocet), naproxen (such as Anaprox, Aleve, Naprosyn).

Generic Gabapentin can be used together with other seizures medicines.

Be very careful with Generic Gabapentin if you suffer from or have a history of heart, kidney or liver disease.

Be careful with Generic Gabapentin if you are going to have a surgery.

Children should be very careful with Generic Gabapentin because it can cause changes in behavior.

If you experience drowsiness and dizziness while taking Generic Gabapentin you should avoid any activities such as driving or operating machinery.

Avoid alcohol.

It can be dangerous to stop Generic Gabapentin taking suddenly.

Gabapentin Frequently asked questions

Q: What does Generic Gabapentin mean?

A: Generic Gabapentin is the medication of high quality, which is taken in treatment of seizures. Generic Gabapentin can also be used to relieve the pain of diabetic neuropathy and postherpetic neuralgia. It is taken to prevent and treat hot flashes in women with menopause or breast cancer. Generic Gabapentin can be used together with other seizures medicines.

Q: What is the target?

A: The target of this perfect remedy is the treatment of seizures. Generic Gabapentin can also be used to relieve the pain of diabetic neuropathy and postherpetic neuralgia. It is taken to prevent and treat hot flashes in women with menopause or breast cancer.

Q: What are generic and brand names of Generic Gabapentin?

A: The brand names of Generic Gabapentin are Gabapentin, Gabarone. The generic name of Generic Gabapentin is Gabapentin.

Q: In what way does Generic Gabapentin operate?

Gabapentin Drug Interaction

Drug interactions can change how gabapentin and your other medications work, or even increase your risk for serious side effects. This document does not contain all possible drug interactions. Be sure to keep a list of all the products you use (including prescription and nonprescription drugs, as well as herbal products) and share it with your clinician and pharmacist. Do not start, stop, or change the dosage of any medicines without your licensed medical professional’s approval.

A product that may interact with gabapentin: orlistat.

Tell your clinician or pharmacist if you use other products that cause drowsiness, like drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), opioid pain or cough relievers (such as codeine, hydrocodone), antihistamines (such as cetirizine, diphenhydramine), muscle relaxants (such as carisoprodol, cyclobenzaprine), alcohol or marijuana (cannabis).

Be sure to also check the labels on all of your medications (including cough-and-cold or allergy products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those medications safely.

Do not use this medication with other medications that contain gabapentin (including gabapentin enacarbil).

Gabapentin may interfere with certain laboratory tests for urine protein. Make sure laboratory personnel and all your licensed medical professionals know you use this drug.

A: Generic Gabapentin is acting by affecting certain nerves and chemicals which cause seizures and pain. It is anticonvulsant.

Gabapentin Marketing Information

Gabapentin is sold in pharmcies as “Neurontin”.  It is also possible to purchase Neurontin in online store.  Gabapentin also can be sold as: Abaglin, Algia, Alidial, Alpentin, Apoab, Bapex, Blugat, Bosrontin, Brilian, Dineurin, Edion, Epiven, Epleptin, Equipax, Gabadoz, Gabagamma, Gabahasan, Gabahexal, Gabalept, Gabalich, Gabamerck, Gabanet, Gabaneural, Gabantin, Gabapen, Gabapentina, Gabape

In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.

In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.

Gabapentin Manufacturers

      • Actavis elizabeth llc
      • Amneal pharmaceuticals ny llc
      • Apotex inc etobicoke site
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      • Hikma pharmaceuticals
      • Invagen pharmaceuticals inc
      • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
      • Mutual pharmaceutical co inc
      • Ranbaxy laboratories ltd
      • Sandoz inc
      • Sun pharmaceutical industries ltd
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      • Watson laboratories inc
      • Pfizer pharmaceuticals ltd
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      • Glenmark generics ltd
      • Matrix laboratories ltd
      • Teva pharmaceuticals usa inc

Gabapentin Packagers

      • 4uOrtho LLC
      • Actavis Group
      • Aidarex Pharmacuticals LLC
      • Amerisource Health Services Corp.
      • Amneal Pharmaceuticals
      • Apotex Inc.
      • Apotheca Inc.
      • A-S Medication Solutions LLC
      • Aurobindo Pharma Ltd.
      • Blenheim Pharmacal
      • Blu Pharmaceuticals LLC
      • Bryant Ranch Prepack
      • Camber Pharmaceuticals Inc.
      • Cardinal Health
      • Comprehensive Consultant Services Inc.
      • Corepharma LLC
      • Coupler Enterprises Inc.
      • Dispensing Solutions
      • Diversified Healthcare Services Inc.
      • Eon Labs
      • Fusion Pharmaceuticals LLC
      • Glenmark Generics Ltd.
      • Golden State Medical Supply Inc.
      • Greenstone LLC
      • H.J. Harkins Co. Inc.
      • Heartland Repack Services LLC
      • Hikma Pharmaceuticals
      • Innoviant Pharmacy Inc.
      • Ivax Pharmaceuticals
      • Kaiser Foundation Hospital
      • Keltman Pharmaceuticals Inc.
      • Lake Erie Medical and Surgical Supply
      • Living Well Pharmacy Inc.
      • Major Pharmaceuticals
      • Mckesson Corp.
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      • Mylan
      • Neuman Distributors Inc.
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      • Nucare Pharmaceuticals Inc.
      • Palmetto Pharmaceuticals Inc.
      • PCA LLC
      • PD-Rx Pharmaceuticals Inc.
      • Pfizer Inc.
      • Pharmaceutical Packaging Center
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      • Physicians Total Care Inc.
      • Preferred Pharmaceuticals Inc.
      • Prepak Systems Inc.
      • Professional Co.
      • Ranbaxy Laboratories
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Alcohol Withdrawal

What is Alcohol Withdrawal?

Alcohol withdrawal is the changes the body goes through when a person suddenly stops drinking after prolonged and heavy alcohol use. Symptoms include trembling (shakes), insomnia, anxiety, and other physical and mental symptoms.

Alcohol has a slowing effect (also called a sedating effect or depressant effect) on the brain. In a heavy, long-term drinker, the brain is almost continually exposed to the depressant effect of alcohol. Over time, the brain adjusts its own chemistry to compensate for the effect of the alcohol. It does this by producing naturally stimulating chemicals (such as serotonin or norepinephrine, which is a relative of adrenaline) in larger quantities than normal.

If the alcohol is withdrawn suddenly, the brain is like an accelerated vehicle that has lost its brakes. Not surprisingly, most symptoms of withdrawal are symptoms that occur when the brain is overstimulated.

The most dangerous form of alcohol withdrawal occurs in about 1 out of every 20 people who have withdrawal symptoms. This condition is called delirium tremens (also called DTs).

In delirium tremens, the brain is not able to smoothly readjust its chemistry after alcohol is stopped. This creates a state of temporary confusion and leads to dangerous changes in the way your brain regulates your circulation and breathing. The body’s vital signs such as your heart rate or blood pressure can change dramatically or unpredictably, creating a risk of heart attack, stroke or death.

Symptoms

If your brain has adjusted to your heavy drinking habits, it takes time for your brain to adjust back. Alcohol withdrawal symptoms occur in a predictable pattern after your last alcohol drink. Not all symptoms develop in all patients:

  • Tremors (shakes) — These usually begin within 5 to 10 hours after the last alcohol drink and typically peak at 24 to 48 hours. Along with tremors (trembling), you can have a rapid pulse, an increase in blood pressure, rapid breathing, sweating, nausea and vomiting, anxiety or a hyper-alert state, irritability, nightmares or vivid dreams, and insomnia.
  • Alcohol hallucinosis — This symptom usually begins within 12 to 24 hours after your last drink, and may last as long as 2 days once it begins. If this happens, you hallucinate (see or feel things that are not real). It is common for people who are withdrawing from alcohol to see multiple small, similar, moving objects. Sometimes the vision is perceived to be crawling insects or falling coins. It is possible for an alcohol withdrawal hallucination to be a very detailed and imaginative vision.
  • Alcohol withdrawal seizures — Seizures may occur 6 to 48 hours after the last drink, and it is common for several seizures to occur over several hours. The risk peaks at 24 hours.
  • Delirium tremens — Delirium tremens commonly begins two to three days after the last alcohol drink, but it may be delayed more than a week. Its peak intensity is usually four to five days after the last drink. This condition causes dangerous shifts in your breathing, your circulation and your temperature control. It can cause your heart to race dangerously or can cause your blood pressure to increase dramatically, and it can cause dangerous dehydration. Delirium tremens also can temporarily reduce the amount of blood flow to your brain. Symptoms can include confusion, disorientation, stupor or loss of consciousness, nervous or angry behavior, irrational beliefs, soaking sweats, sleep disturbances and hallucinations.

Diagnosis

Alcohol withdrawal is easy to diagnose if you have typical symptoms that occur after you stop heavy, habitual drinking. If you have a past experience of withdrawal symptoms, you are likely to have them return if you start and stop heavy drinking again. There are no specific tests that can be used to diagnose alcohol withdrawal.

If you have withdrawal symptoms from drinking, then you have consumed enough alcohol to damage other organs. It is a good idea for your doctor to examine you carefully and do blood tests, checking for alcohol-related damage to your liver, heart, the nerves in your feet, blood cell counts, and gastrointestinal tract. Your doctor will evaluate your usual diet and check for vitamin deficiencies because poor nutrition is common when someone is dependent on alcohol.

It is usually difficult for people who drink to be completely honest about how much they’ve been drinking. You should report your drinking history straightforwardly to your doctor so you can be treated safely for withdrawal symptoms.

Expected Duration

Symptoms of alcohol withdrawal typically improve within five days, though a small number of patients may have prolonged symptoms, lasting weeks.

Prevention

Alcoholism is caused by many factors. If you have a sibling or parent with alcoholism, then you are three or four times more likely than average to develop alcoholism. Some people with family histories of alcoholism choose to abstain from drinking since this is a guaranteed way to avoid developing alcohol dependence. Many people without a family history also develop alcoholism. If you are concerned about your drinking, speak with your doctor.

Treatment

If you have severe vomiting, seizures or delirium tremens, the safest place for you to be treated is in a hospital. For delirium tremens, treatment in an intensive care unit (ICU) is often required. In an ICU, your heart rate, blood pressure, and breathing can be monitored closely in case emergency life-support (such as artificial breathing by a machine) is needed.

Medicines called benzodiazepines can lessen alcohol withdrawal symptoms. Commonly used medicines in this group include chlordiazepoxide (Librium) and lorazepam (Ativan).

Most alcohol abusers who are having withdrawal symptoms have a shortage of several vitamins and minerals and can benefit from nutritional supplements. In particular, alcohol abuse can create a shortage of folate, thiamine, magnesium, zinc and phosphate. It also can cause low blood sugar.