Fioricet contains Butalbital, Acetaminophen, and caffeine. A lot of other pain relievers contain Butalbital, Acetaminophen, and caffeine too. I can only list some common over the counter medicines that contain Acetaminophen: Actifed, Alka-Seltzer, Plus Liquid Gels, Anacin, Cepacol, Contac, Coricidin, Dayquil, Dimetapp, Dristan, Excedrin, Feverall … In some cases, Fioricet can interact with other drugs …